Basosquamous carcinoma involving the anterior skull base: a neglected tumor treated using intraoperative navigation as a guide to achieve safe resection margins

Gregoire C, Adler D, Madey S, Bell B, JOMS. 2011 Jan;69(1):230-6.


Basosquamous carcinoma (BSC) or metatypical carcinoma is a rare and controversial form of basal cell carcinoma (BCC) that was first described by MacCormac in 1910. Numerous theories have been described in the literature regarding its origin but it is generally accepted as a variant of BCC that differentiates into squamous cell carcinoma (SCC). At present, it has an unsatisfactorily established phenotype but is considered to behave more like an SCC than a BCC. A reflection of this fact is its more aggressive nature with a significantly increased incidence of local and distant metastasis. It must be distinguished histologically from so-called “collision” tumors, which represent SCC and BCC arising as separate entities in the same area. We present a unique case of a neglected, large, and locally advanced case of BCC originating from the nose, but extending into the paranasal sinuses, orbit, and anterior skull base, that was treated with en bloc surgical resection using intraoperative navigation to assist in treatment planning and margin clearance.

The Need for Concomitant Bone Grafting During Maxillomandibular Advancement for the Treatment of Obstructive Sleep Apnea Syndrome

Goodday RG, Gregoire CE., JOMS. 2007 Sept; 65(9):42.


Obstructive sleep apnea syndrome (OSAS) is a serious, potentially life-threatening medical condition with a wide range of deleterious health side effects. The benefits of Maxillomandibular Advancement (MMA) surgery to treat OSAS in selected patients are well recognized. Controversy exists regarding the need to perform a concomitant bone graft to ensure stability and good bone healing at the osteotomy site in MMA patients. This additional procedure increases surgical time, expense and morbidity. The purpose of this study is to determine the incidence of post-operative mobility of the maxilla and or mandible in a group of patients undergoing MMA without concomitant bone graft for the treatment of OSAS.